1、rTMS可导致神经突触可塑性发生变化,促进睡眠,提高睡眠质量,是有效诱导脑电慢波活动的非药物治疗手段之一。而脑电慢波活动(slow activity,SWA)是一项可以反映睡眠效率的敏感指标,与神经突触可塑性和学习记忆能力关系密切。
2、rTMS可以增加脑源性神经营养因子、突触生长相关蛋白及突触素的表达水平,促进大脑皮质可塑性改变。而rTMS正是可能通过对大脑皮质可塑性的作用而治疗失眠。
3、rTMS可能通过影响大脑神经网络及神经递质水平而治疗失眠。
4、rTMS可能通过调节松果体内褪黑激素的合成与分泌对机体睡眠-醒觉周期进行调节,而治疗失眠。
5、rTMS可能通过调节机体免疫防御系统的作用而治疗失眠。
1.Siber MH.Clinical practice.Chronic insomnia[J].N Engl J Med,2005,353(8):803-810.
2.Speer AM,Willis MW,Herscovitch P,et al.Intensity-dependent regional cerebral blood flow during 1-Hz repetitive transcranial magnetic stilmulation(rTMS)in healthy volunteers studied with H2150 positron emission tomography:Ⅱ.Effects of prefrontal cortex rTMS[J].Bionl Psychiatry,2003,54(8):826-832.
3.Wassermann EM,Lisanby SH.Therapeutic application of repetitive transcranial magnetic stimulation:a review[J].Clin Neurophysiol,2001,112(8):1367-1770.
4.Vgontzas AN,Zoumakis E,Bixler EO,et al.Adverse effects of modest sleep restriction on sleepiness,performance,and inflammatory cytokines[J].J Clin Endocrinol Metab,2004,89(5):2119-2126.
5.Everson CA.Clinical assessment of blood leukocytes,serum cytokines,and serum immunoglobulins as responses to sleep deprivation in laboratory rats[J].Am J Physiol Regul Integr Comp Physiol,2005,289(4):1054-1063.
6.Reiter RJ.Static and extremely low frequency electromagnetic field exposure:reported effects on the circadian production of melatonin[J].J Cell Biochem,1993,51(4):39--403.
7.Ben-Chachar D,Gazawi H,Riboyad-Levin J,et al.Chronic repetitive transcranial magnetic stilmulation alters beta-adrenergic and 5-HT2 receptor characteristics in rat brain[J].Brain Res,1999,816(1):78-83.